Gamma interferon is critical for resistance to Theiler's virus-induced demyelination.
نویسندگان
چکیده
Administration of neutralizing monoclonal antibody to gamma interferon increased Theiler's virus-induced demyelination and virus antigen persistence in the spinal cord in susceptible SJL/J mice and completely abrogated resistance such that all C57BL/10SNJ mice developed demyelination. These experiments support the hypothesis that gamma interferon is critically important for resistance to Theiler's virus-induced disease but is not required for myelin destruction.
منابع مشابه
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ورودعنوان ژورنال:
- Journal of virology
دوره 69 11 شماره
صفحات -
تاریخ انتشار 1995